Description

This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.

LL-37 5mg – Antimicrobial Research Peptide

Product Overview

LL-37 is a synthetic peptide that mimics the naturally occurring human antimicrobial peptide derived from the cathelicidin antimicrobial peptide (CAMP) gene. As one of the only known human cathelicidins, LL-37 plays a crucial role in the innate immune system. It exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi, and has also been studied for its wound healing, immune modulation, and tissue repair properties.

Researchers are particularly interested in LL-37’s dual functionality—not only as a pathogen defense agent but also as a peptide involved in cellular signaling, angiogenesis, and inflammation control.

Key Research Applications

• Antimicrobial Activity: Demonstrated efficacy against gram-positive and gram-negative bacteria, enveloped viruses, and fungi.

• Wound Healing & Tissue Regeneration: Promotes epithelial cell migration, angiogenesis, and wound closure.

• Immunomodulation: Influences cytokine release, inflammation pathways, and immune cell activation.

• Autoimmune and Inflammatory Research: Studied for its role in psoriasis, lupus, and inflammatory lung conditions.

Scientific Background

LL-37 is a 37-amino acid peptide fragment of the human cationic antimicrobial protein-18 (hCAP-18). Its amphipathic structure allows it to insert into microbial membranes, disrupting their integrity and leading to cell death. Beyond its antimicrobial role, LL-37 has shown involvement in promoting chemotaxis, modulating Toll-like receptor responses, and supporting tissue regeneration.

Studies have explored LL-37 in areas such as:

• Chronic wounds and diabetic ulcers

• Cystic fibrosis and respiratory tract infections

• Psoriasis and inflammatory skin disorders

• Immune defense and sepsis models

LL-37 and Wound Healing

LL-37’s wound healing effects are linked to its ability to recruit immune cells, stimulate keratinocyte migration, and promote angiogenesis. Research in murine and in vitro models suggests that LL-37 may accelerate healing, especially in infected or chronic wounds.

LL-37 and Respiratory Health

In respiratory research, LL-37 has been studied for its potential to improve epithelial barrier function, reduce inflammation, and combat microbial colonization in the lungs—making it a molecule of interest in diseases like asthma, COPD, and cystic fibrosis.

LL-37 and Autoimmune Research

Despite its protective qualities, overexpression or dysregulation of LL-37 has been implicated in autoimmune disorders. It serves as a useful model for studying immune system imbalances and inflammatory feedback loops.

Product Specifications

Handling & Storage

• Storage: LL-37 should be stored at -20°C in a dry, light-protected environment. Once reconstituted, it should be used promptly or aliquoted and frozen for later use.

• Reconstitution: Use sterile, bacteriostatic water or suitable buffer for dissolution under aseptic conditions.

Legal Disclaimer

This product is for laboratory research use only. It is not approved by the FDA for medical, diagnostic, or therapeutic use in humans or animals. The information provided on this page is for educational purposes only.

Ready to Advance Your Research?

Order LL-37 5mg today and explore its potential in your antimicrobial, immunological, and regenerative research projects. Trust Molecular Solutions Peptides for purity, consistency, and scientific integrity.