Description
This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide that selectively stimulates the release of growth hormone (GH) from the pituitary gland. It mimics the action of ghrelin, a naturally occurring hormone that regulates GH secretion, without significantly affecting other pituitary hormones, such as cortisol, prolactin, or thyroid-stimulating hormone. Ipamorelin’s mechanism of action involves binding to the ghrelin receptor, triggering GH release, which may influence various anabolic processes, including appetite regulation, fat metabolism, and energy usage.
Ipamorelin and Growth Hormone Release
Ipamorelin acts as a potent growth hormone secretagogue by mimicking ghrelin, the body’s natural GH-stimulating hormone. It binds to the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), and triggers a cascade of events leading to selective GH release from the pituitary gland.
A key advantage of ipamorelin is its selectivity, as it stimulates GH release without significantly affecting other pituitary hormones. This makes it distinct from other GH-releasing peptides and similar in function to growth hormone-releasing hormone (GHRH).
Ipamorelin and Muscle Strength
In studies involving rats treated with glucocorticoids (which are known to cause muscle wasting), ipamorelin demonstrated the ability to preserve muscle strength. Researchers measured this by assessing the maximum tetanic tension of calf muscles. This suggests that ipamorelin might support muscle function under conditions where muscle loss is a concern.
Although direct human studies on ipamorelin’s effects on muscle mass and strength are limited, its classification as a growth hormone secretagogue indicates potential in promoting muscle growth and maintenance.
Ipamorelin and Bone Health
Research has explored ipamorelin’s impact on bone health. A study published in the Journal of Endocrinology (2000) found that continuous administration of ipamorelin over 12 weeks increased bone mineral content in the tibia and vertebrae of adult female rats. However, this increase appeared proportional to overall body weight, suggesting that its effects on bone health may be part of broader growth-promoting properties.
Ipamorelin and Gastrointestinal Motility Disorders
Studies suggest that ipamorelin may positively impact gastrointestinal motility by accelerating gastric emptying and improving gastric contractility. These potential therapeutic applications are promising, particularly in addressing postoperative ileus and other gastrointestinal motility disorders.
Ipamorelin and Diabetes
Research on rats indicates that ipamorelin can enhance insulin release from pancreatic tissue in both healthy and diabetic subjects. This effect was observed across various concentrations of the peptide. The mechanism appears to involve multiple pathways, including interactions with calcium channels and adrenergic receptors, highlighting ipamorelin’s potential for further study in diabetes research.
Ipamorelin as a Ghrelin Receptor Probe
Ipamorelin functions as a selective ghrelin receptor agonist, making it valuable for research into ghrelin receptor-mediated mechanisms. Its ability to bind to and activate ghrelin receptors allows researchers to study physiological processes influenced by these receptors.
One study found that ipamorelin effectively attenuated visceral and somatic nociception through ghrelin receptor-mediated mechanisms, suggesting potential applications in pain modulation research. Additionally, researchers have used ipamorelin as a template for developing novel compounds targeting the ghrelin receptor, emphasizing its utility as a structural basis for ghrelin receptor studies.
Legal Disclaimer
This product is sold as a pure research compound and is not intended for human consumption or use as a dietary supplement, drug, or treatment. It is provided solely for laboratory research purposes and must not be used for diagnostic or therapeutic purposes, in food, cosmetics, or any medical applications.
The statements on this website have not been evaluated by the U.S. Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. All products are for research and development use only.
Important Safety Information
- Keep this product out of the reach of children.
- Limited research is available on this material, and improper handling or use may pose risks or result in adverse effects.
- This product is sold solely as a raw material for research purposes, and its purity and quality are attested exclusively for these purposes.
- It is intended for handling only by qualified researchers with the necessary knowledge and equipment to safely manage such materials.
By purchasing, you agree to indemnify Molecular Solutions Peptides against any adverse effects that may arise from improper handling or use of this product.
Educational Notice
All information on this website is provided solely for educational purposes. These products are not pharmaceuticals or medications. The Food and Drug Administration (FDA) has not approved them for the treatment, prevention, or cure of any disease, medical condition, or ailment.
